Description

4-(Bromomethyl)-3-(trifluoromethyl)benzonitrile is a versatile and high-value aromatic building block containing both bromomethyl and trifluoromethyl functional groups. This compound is critical for the synthesis of complex molecules where the introduction of these reactive handles enables further structural elaboration. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced intermediates. The presence of the electron-withdrawing nitrile and trifluoromethyl groups also makes it a valuable precursor for materials science applications.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group often enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Functional Material Precursor: Employed in the synthesis of organic electronic materials, liquid crystals, and advanced polymers where its aromatic core and functional groups impart specific electronic or physical properties.
• Cross-Coupling Reactions: The bromomethyl moiety acts as an excellent electrophile for nucleophilic substitution (SN2) and as a substrate for metal-catalyzed cross-couplings, such as Suzuki or Buchwald-Hartwig amination, after functional group transformation.
• Chemical Biology Probes: Useful for the design and synthesis of molecular probes and tags for studying biological processes, leveraging its reactivity for bioconjugation.

Basic Information

Product Name	4-(Bromomethyl)-3-(trifluoromethyl)benzonitrile
CAS No.	853368-32-8
Molecular Formula	C9H5BrF3N
Molecular Weight	264.04 g/mol
Synonyms	3-(Trifluoromethyl)-4-(bromomethyl)benzonitrile; 4-Bromomethyl-3-trifluoromethylbenzonitrile; 2-Bromomethyl-α,α,α-trifluoro-p-tolunitrile; Benzonitrile, 4-(bromomethyl)-3-(trifluoromethyl)-; p-Cyanobenzyl bromide, 3-trifluoromethyl-
EINECS	Contact for details

Quality Control

Our 4-(Bromomethyl)-3-(trifluoromethyl)benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade intermediate synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to the light-sensitive nature and reactivity of the bromomethyl group, prolonged exposure to light or moisture should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.