Description

4-Amino-5-Iodo-2-(Trifluoromethyl)Benzonitrile is a high-value, multi-functional aromatic intermediate featuring amino, iodo, cyano, and trifluoromethyl substituents. This unique combination of functional groups makes it a critical building block for synthesizing complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in developing new herbicides, fungicides, and pesticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Serves as a monomer or functionalizing agent for advanced polymers and liquid crystals, leveraging its electron-withdrawing groups.
• Organic Synthesis Building Block: The reactive iodo and amino groups allow for versatile cross-coupling and further functionalization reactions (e.g., Buchwald-Hartwig amination, Sonogashira coupling).
• Fluorine Chemistry Studies: An important compound for research into the effects of fluorine substitution on molecular properties and reactivity.

Basic Information

Product Name	4-Amino-5-Iodo-2-(Trifluoromethyl)Benzonitrile
CAS No.	852569-35-8
Molecular Formula	C8H4F3IN2
Molecular Weight	312.03 g/mol
Synonyms	2-(Trifluoromethyl)-4-amino-5-iodobenzonitrile; 4-Amino-5-iodo-2-(trifluoromethyl)benzonitrile; 5-Iodo-4-amino-2-(trifluoromethyl)benzonitrile; 2-Cyano-5-iodo-4-(trifluoromethyl)aniline; Benzonitrile, 4-amino-5-iodo-2-(trifluoromethyl)-; 852569-35-8
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our fine chemical intermediates. Production of 4-Amino-5-Iodo-2-(Trifluoromethyl)Benzonitrile is monitored via advanced analytical techniques including HPLC, GC, and NMR to ensure batch-to-batch consistency and high purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C to minimize oxidation and degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.