Description

2-Pyrrolidinone, 3,3-Difluoro-5-(Hydroxymethyl)-, (5S)- is a high-purity, chiral fluorinated pyrrolidinone derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in its unique stereochemistry and functional groups, which make it an essential building block for the synthesis of complex, bioactive molecules. This compound is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of novel drug candidates, especially in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced, fluorinated active ingredients for crop protection products, leveraging the fluorine atoms for enhanced biological activity and metabolic stability.
• Chemical Biology Probe Development: Serves as a scaffold for creating molecular probes to study enzyme mechanisms and biological pathways due to its reactive hydroxymethyl group and defined stereochemistry.
• Material Science Research: Potential monomer or precursor for specialty polymers and advanced materials requiring specific fluorinated and heterocyclic components.

Basic Information

Product Name	2-Pyrrolidinone, 3,3-Difluoro-5-(Hydroxymethyl)-, (5S)-
CAS No.	850689-13-3
Molecular Formula	C5H7F2NO2
Molecular Weight	151.11 g/mol
Synonyms	(5S)-3,3-Difluoro-5-(hydroxymethyl)pyrrolidin-2-one; (5S)-3,3-Difluoro-5-(hydroxymethyl)-2-pyrrolidinone; (S)-3,3-Difluoro-5-(hydroxymethyl)pyrrolidin-2-one; 3,3-Difluoro-5-(hydroxymethyl)-2-pyrrolidinone, (5S)-; (S)-3,3-Difluoro-5-(hydroxymethyl)-2-pyrrolidinone; 850689-13-3; (5S)-3,3-Difluoro-5-(hydroxymethyl)-2-pyrrolidone
EINECS	Contact for details

Quality Control

Our 2-Pyrrolidinone, 3,3-Difluoro-5-(Hydroxymethyl)-, (5S)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical development. Certificates of Analysis (COA) with full chromatographic data (HPLC, GC) and spectroscopic confirmation (NMR, MS) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.