Description

(S)-(-)-3,3'-Bis(3,5-Bis(Trifluoromethyl)phenyl)-1,1'-binaphthyl-2,2'-diol is a high-value, chiral binaphthol derivative distinguished by its electron-deficient trifluoromethylated aromatic substituents. This compound matters as a sophisticated ligand and building block for asymmetric catalysis, enabling the synthesis of enantiomerically pure pharmaceuticals and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel synthetic methodologies and high-performance catalysts.

Application

• Asymmetric Catalysis: Serving as a privileged chiral ligand for transition metal-catalyzed reactions, including hydrogenation, cross-coupling, and C-H activation.
• Pharmaceutical Intermediate: A key precursor in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and complex molecules.
• Organocatalyst Synthesis: Used as a core scaffold for developing novel organocatalysts for enantioselective transformations.
• Material Science: A building block for chiral polymers, liquid crystals, and other functional materials with specific optical properties.
• Analytical Chemistry: Employed as a chiral selector or stationary phase modifier in chromatography for enantiomer separation.
• Agrochemical Research: Utilized in the development of chiral pesticides and herbicides with improved efficacy and environmental profiles.

Basic Information

Product Name	(S)-(-)-3,3'-Bis(3,5-Bis(Trifluoromethyl)phenyl)-1,1'-binaphthyl-2,2'-diol
CAS No.	849939-13-5
Molecular Formula	C46H24F12O2
Molecular Weight	812.67 g/mol
Synonyms	(S)-3,3'-Bis[3,5-bis(trifluoromethyl)phenyl]-1,1'-bi-2-naphthol; (S)-3,3'-Bis(3,5-bis(trifluoromethyl)phenyl)-BINOL; (S)-(-)-DTB-BINOL; (S)-3,3'-Bis(3,5-di(trifluoromethyl)phenyl)-BINOL; (S)-BINOL-DTBM; (S)-3,3'-Bis(perfluoro-tert-butylphenyl)-BINOL (common misnomer); (S)-DTBM-BINOL; (S)-(-)-3,3'-Bis(3,5-di(trifluoromethyl)phenyl)-1,1'-binaphthalene-2,2'-diol
EINECS	Contact for details

Quality Control

Our (S)-(-)-3,3'-Bis(3,5-Bis(Trifluoromethyl)phenyl)-1,1'-binaphthyl-2,2'-diol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and enantiomeric purity, meeting the stringent requirements for research and process development. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; handle and store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.