Description

Benzene, 1,3-Difluoro-5-Nitro-2-(Phenylmethoxy)- is a specialized fluorinated nitroaromatic compound with a benzyloxy substituent, serving as a high-value synthetic intermediate. Its unique molecular architecture, featuring both electron-withdrawing and protecting groups, makes it a critical building block for constructing complex molecules in advanced research and development. This compound is primarily utilized by pharmaceutical and agrochemical R&D laboratories for the synthesis of novel active ingredients, particularly in the development of fluorinated drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Building block for developing novel herbicides and fungicides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Used in the development of advanced organic electronic materials, such as fluorinated polymers and liquid crystals.
• Chemical Biology Probes: Serves as a scaffold for creating fluorescent tags and molecular probes due to its nitro-aromatic and fluorinated structure.
• Organic Synthesis: Versatile intermediate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution reactions.

Basic Information

Product Name	Benzene, 1,3-Difluoro-5-Nitro-2-(Phenylmethoxy)-
CAS No.	847861-84-1
Molecular Formula	C₁₃H₉F₂NO₃
Molecular Weight	265.22 g/mol
Synonyms	1,3-Difluoro-5-nitro-2-(phenylmethoxy)benzene; 2-(Benzyloxy)-1,3-difluoro-5-nitrobenzene; 2-Benzyloxy-1,3-difluoro-5-nitrobenzene; 5-Nitro-1,3-difluoro-2-(phenylmethoxy)benzene; Benzene, 1,3-difluoro-5-nitro-2-(phenylmethoxy)-; 847861-84-1; 2-(Benzyloxy)-1,3-difluoro-5-nitro-benzene
EINECS	Contact for details

Quality Control

Our Benzene, 1,3-Difluoro-5-Nitro-2-(Phenylmethoxy)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.