Description

[1-(2-Fluoro-Phenyl)-2-Hydroxy-Ethyl]-Carbamic Acid tert-Butyl Ester is a high-purity, protected amino alcohol derivative of significant interest in advanced organic synthesis. This compound serves as a versatile and critical building block for the development of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries to introduce chiral, fluorinated motifs into target molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and oncology research.
• Peptidomimetic Chemistry: Used to incorporate fluorinated phenylglycinol analogs into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a precursor for chiral auxiliaries, ligands, or catalysts due to its defined stereogenic center and protected functional groups.
• Agrochemical Research: Building block for novel fluorinated pesticides and herbicides, leveraging the fluorine atom's ability to modulate lipophilicity and biological activity.
• Material Science: Potential monomer or modifier in the synthesis of specialty polymers with tailored properties.

Basic Information

Product Name	[1-(2-Fluoro-Phenyl)-2-Hydroxy-Ethyl]-Carbamic Acid tert-Butyl Ester
CAS No.	847686-72-0
Molecular Formula	C₁₃H₁₈FNO₃
Molecular Weight	255.29 g/mol
Synonyms	N-Boc-2-Amino-1-(2-fluorophenyl)ethanol; tert-Butyl N-[1-(2-fluorophenyl)-2-hydroxyethyl]carbamate; (R/S)-N-Boc-2-Amino-2-(2-fluorophenyl)ethanol; 1-(2-Fluorophenyl)-2-[(tert-butoxycarbonyl)amino]ethanol; BOC-2-Amino-1-(2-fluorophenyl)ethanol; N-(tert-Butoxycarbonyl)-2-amino-1-(2-fluorophenyl)ethanol; 2-[(tert-Butoxycarbonyl)amino]-1-(2-fluorophenyl)ethan-1-ol
EINECS	Contact for details

Quality Control

Our [1-(2-Fluoro-Phenyl)-2-Hydroxy-Ethyl]-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure identity, potency, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to meet specific customer or regulatory requirements, including ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomerically pure) or as specified
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.