Description

2,4-Difluoro-3-Methylbenzonitrile is a high-purity fluorinated aromatic nitrile building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. Industries requiring precise molecular construction, such as medicinal chemistry for drug discovery and crop protection science, rely on this specialty chemical for introducing difluoro-methyl-substituted benzonitrile motifs into target structures.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the difluoro and nitrile groups contribute to biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for advanced display technologies.
• Organic Electronic Materials: Employed in the development of organic semiconductors and electron-transport materials for OLEDs and photovoltaic cells.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D exploring new fluorination chemistry and heterocyclic compound synthesis.

Basic Information

Product Name	2,4-Difluoro-3-Methylbenzonitrile
CAS No.	847502-87-8
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	3-Methyl-2,4-difluorobenzonitrile; 2,4-Difluoro-3-methylbenzonitrile; Benzonitrile, 2,4-difluoro-3-methyl-; 2,4-Difluoro-m-toluonitrile; 847502-87-8 (CAS); 3-Methyl-2,4-difluorobenzene carbonitrile
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-3-Methylbenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your most critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.