Description

3,4-Difluoro-2-Methylbenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its core value lies in its unique substitution pattern, which provides a versatile scaffold for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily needed by R&D chemists and process development scientists working on novel active ingredients, particularly in the areas of medicinal chemistry and crop protection.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoro-methylbenzonitrile moiety imparts desirable biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of advanced organic electronic materials, such as semiconductors and liquid crystals, due to its electron-withdrawing nitrile group and fluorine atoms.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	3,4-Difluoro-2-Methylbenzonitrile
CAS No.	847502-83-4
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	2-Methyl-3,4-difluorobenzonitrile; 3,4-Difluoro-2-methylbenzonitrile; Benzonitrile, 3,4-difluoro-2-methyl-; 2-Cyano-6-fluoro-3-methylbenzene; 2-Cyano-1,2-difluoro-3-methylbenzene (isomer); 847502-83-4; 3,4-Difluoro-o-tolunitrile
EINECS	Contact for details

Quality Control

Our 3,4-Difluoro-2-Methylbenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.