Description

6-Amino-3-Bromo-2-Fluoro-Benzonitrile is a high-value, multi-functional aromatic nitrile building block. This compound matters for its unique trifunctional molecular architecture, combining an amine, a halogen, and a nitrile group, which enables diverse and complex synthetic pathways. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting kinase inhibition and other biological pathways.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its halogen and nitrile functionalities.
• Material Science Research: Serves as a building block for advanced polymers, liquid crystals, and organic electronic materials due to its rigid, substituted benzene core.
• Chemical Biology Probes: Employed in the creation of fluorescent tags, affinity labels, and other molecular probes for diagnostic and research applications.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed Suzuki, Sonogashira, and Buchwald-Hartwig amination reactions.
• Nitrile Transformation: The cyano group can be hydrolyzed to carboxylic acids, reduced to amines, or used to form heterocycles like tetrazoles and triazoles.

Basic Information

Product Name	6-Amino-3-Bromo-2-Fluoro-Benzonitrile
CAS No.	845866-92-4
Molecular Formula	C7H4BrFN2
Molecular Weight	215.02 g/mol
Synonyms	3-Bromo-2-fluoro-6-aminobenzonitrile; 2-Fluoro-6-amino-3-bromobenzonitrile; 6-Amino-3-bromo-2-fluorobenzonitrile; 2-Cyano-4-bromo-3-fluoroaniline; 4-Bromo-3-fluoro-2-cyanoaniline; Benzonitrile, 6-amino-3-bromo-2-fluoro-; 845866-92-4; Contact for additional synonyms
EINECS	Contact for details

Quality Control

Our 6-Amino-3-Bromo-2-Fluoro-Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed specifications are provided for each lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.