Description

4-Difluoromethoxy-3-Methoxy-Benzonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluoromethoxy and methoxy substituted benzonitrile structure. This compound is of significant commercial importance for its role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modification. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially in oncology, CNS, and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides where the difluoromethoxy group can influence bioavailability and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials and liquid crystals due to its aromatic nitrile core and fluorine content.
• Fluorine Chemistry Studies: An important substrate for investigating the effects of fluorine substitution on chemical reactivity and physical properties in academic and industrial R&D.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines.

Basic Information

Product Name	4-Difluoromethoxy-3-Methoxy-Benzonitrile
CAS No.	832737-32-3
Molecular Formula	C9H7F2NO2
Molecular Weight	199.16 g/mol
Synonyms	3-Methoxy-4-(difluoromethoxy)benzonitrile; 4-(Difluoromethoxy)-3-methoxybenzonitrile; Benzonitrile, 4-(difluoromethoxy)-3-methoxy-; 832737-32-3; 4-Difluoromethoxy-3-methoxy-benzonitrile; 3-Methoxy-4-difluoromethoxybenzonitrile
EINECS	Contact for details

Quality Control

Our 4-Difluoromethoxy-3-Methoxy-Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to cGMP standards for pharmaceutical applications, and we support regulatory filings with necessary documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.