Description

Manganese Bleomycin CAS NO 89725-97-3 is a metal-chelated derivative of the bleomycin family of glycopeptide antibiotics, where manganese is complexed to the bleomycin core. This complexation is critical for its role as a model compound in biochemical research, particularly in studies of DNA cleavage mechanisms and oxidative damage. It is primarily utilized by research institutions and pharmaceutical development laboratories investigating novel chemotherapeutic agents and the fundamental biochemistry of metal-dependent enzymes.

Application

• Biochemical Research: Used as a standard or probe in studies of metal-dependent DNA cleavage and strand scission mechanisms.
• Anticancer Agent Studies: Serves as a reference compound in the development and screening of new bleomycin analogues and metallo-chemotherapeutics.
• Enzymology: Employed to investigate the role of transition metals in the activity of bleomycin-family antibiotics and related oxygenases.
• Academic Research: Utilized in university and institutional labs for teaching and advanced research in bioinorganic chemistry and molecular biology.
• Pharmaceutical R&D: Acts as a key intermediate or reference material in the research and development pipeline for oncology drugs.

Basic Information

Product Name	Manganese Bleomycin
CAS No.	89725-97-3
Molecular Formula	C55H84N17O21S2Mn
Molecular Weight	~1435.4 g/mol
Synonyms	Bleomycin Manganese Complex; Manganese-Bleomycin; Manganese Bleomycin Sulfate; Bleomycin Mn; NSC-729153; Bleomycin A2 Manganese Complex; Manganese(II) Bleomycin
EINECS	Contact for details

Quality Control

Our Manganese Bleomycin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is characterized using advanced analytical techniques, including HPLC for purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be kept under anhydrous conditions. For long-term storage, consider desiccated or inert atmosphere conditions to maintain stability.

Specification

Item	Specification
Appearance	Light-colored to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.