Description

5-Chloro-2-(Trifluoromethyl)Benzonitrile is a versatile aromatic nitrile building block characterized by its chloro and trifluoromethyl substituents. This compound is highly valued for its role as a key intermediate in the synthesis of advanced agrochemicals and pharmaceuticals, where its unique halogenated structure imparts desirable biological activity and metabolic stability. It is primarily sought by research and development chemists, process engineers, and manufacturers in the agrochemical, pharmaceutical, and specialty chemical industries.

Application

• Agrochemical Intermediate: A critical precursor in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl group.
• Pharmaceutical Building Block: Used in medicinal chemistry for constructing active pharmaceutical ingredients (APIs), particularly in candidates targeting central nervous system (CNS) and inflammatory diseases.
• Ligand and Catalyst Synthesis: Serves as a starting material for creating specialized ligands and catalysts used in cross-coupling and other transition metal-catalyzed reactions.
• Material Science Research: Employed in the development of advanced polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing properties.
• Custom Synthesis and Contract Manufacturing: A fundamental substrate for custom chemical synthesis services catering to R&D and scale-up projects.

Basic Information

Product Name	5-Chloro-2-(Trifluoromethyl)Benzonitrile
CAS No.	89223-58-5
Molecular Formula	C8H3ClF3N
Molecular Weight	205.56 g/mol
Synonyms	2-Chloro-5-(trifluoromethyl)benzonitrile; 5-Chloro-α,α,α-trifluoro-o-tolunitrile; 2-Cyano-4-chlorobenzotrifluoride; 4-Chloro-2-(trifluoromethyl)benzonitrile; 5-Chloro-2-trifluoromethylbenzonitrile; Benzonitrile, 5-chloro-2-(trifluoromethyl)-; 89223-58-5
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates and ISO standards for industrial chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.