Description

N(6)-((Dimethylamino)Methylene)Mitomycin C is a chemically modified derivative of the potent antitumor antibiotic Mitomycin C. This compound is of significant interest in pharmaceutical research and development, particularly as a key intermediate or a prodrug candidate in the synthesis of novel chemotherapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on oncology drug discovery and advanced cancer therapy development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel Mitomycin C analogs and targeted cancer therapeutics.
• Oncology Research: Used in biochemical and pharmacological studies to investigate structure-activity relationships (SAR) and mechanisms of action of alkylating agents.
• Prodrug Development: Explored as a potential prodrug candidate designed for selective activation within tumor microenvironments to improve therapeutic index.
• Bioconjugation Studies: Employed in the development of antibody-drug conjugates (ADCs) or other targeted delivery systems due to its modifiable functional group.
• Chemical Biology Tool: Acts as a probe compound in studies of DNA cross-linking and repair pathways in cancer cells.

Basic Information

Product Name	N(6)-((Dimethylamino)Methylene)Mitomycin C
CAS No.	88949-01-3
Molecular Formula	C₁₇H₂₂N₄O₅
Molecular Weight	362.38 g/mol
Synonyms	N(6)-((Dimethylamino)Methylene)Mitomycin C; (Dimethylaminomethylene)mitomycin C; Mitomycin C, N(6)-((dimethylamino)methylene)-; 7-Amino-9a-methoxy-5-methyl-2,4,5,10-tetraazabenzol[cd]azulene-6,8-dione, N(6)-((dimethylamino)methylene)-; N6-((Dimethylamino)methylene)mitomycin C; Mitomycin C dimethylaminomethylene derivative; N(6)-(Dimethylaminomethylene)mitomycin C
EINECS	Contact for details

Quality Control

Our N(6)-((Dimethylamino)Methylene)Mitomycin C is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. For long-term storage, consider storage under an inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.