Description

(-)-Mequitazine is a high-purity, single-enantiomer pharmaceutical intermediate and active ingredient. This compound is valued for its specific stereochemistry, which is critical for targeted biological activity and efficacy in advanced therapeutic applications. It is essential for research and development laboratories, pharmaceutical manufacturers, and fine chemical synthesis requiring a defined chiral building block.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active enantiomer in antihistamine and antiallergic medication formulations.
• Chiral Intermediate: Key building block in the asymmetric synthesis of more complex therapeutic molecules.
• Pharmacological Research: Standard reference compound for studying H1-receptor antagonist mechanisms, pharmacokinetics, and metabolic pathways.
• Analytical Standard: High-purity material for use in method development, validation, and quality control (HPLC, GC, MS) in regulatory and analytical labs.
• Process Development: Used in scaling up and optimizing synthetic routes for commercial pharmaceutical production.

Basic Information

Product Name	(-)-Mequitazine
CAS No.	88598-74-7
Molecular Formula	C20H22N2S
Molecular Weight	322.47 g/mol
Synonyms	(-)-Mequitazine; Levomequitazine; (S)-Mequitazine; Mequitazine, (-)-; 10-[(1S)-1-Methyl-3-pyrrolidinyl]methyl]phenothiazine; LMQZ; LMQ; NSC 339539; Phenothiazine derivative LMQ
EINECS	Contact for details

Quality Control

Our (-)-Mequitazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets stringent specifications for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.