Description

Acrivastine is a potent, second-generation alkylamine antihistamine known for its rapid onset of action and minimal sedative effects. This high-purity active pharmaceutical ingredient (API) is critical for the development of effective allergy relief medications. It is primarily utilized by pharmaceutical manufacturers and R&D organizations in the global healthcare sector for the formulation of oral solid dosage forms.

Application

• Pharmaceutical API: Primary active ingredient in prescription and over-the-counter (OTC) antihistamine medications for the symptomatic relief of seasonal allergic rhinitis (hay fever) and chronic idiopathic urticaria (hives).
• Combination Drug Formulations: Used in fixed-dose combination products with decongestants, such as pseudoephedrine, to provide comprehensive allergy and cold symptom relief.
• Generic Drug Manufacturing: Serves as the key component for producing bioequivalent generic versions of branded antihistamine drugs, ensuring cost-effective treatment options.
• Clinical Research & Development: Employed in preclinical and clinical studies for developing new allergy therapeutics or exploring novel delivery systems (e.g., fast-dissolving tablets).
• Veterinary Pharmaceuticals: Potential application in veterinary medicine for managing allergic conditions in companion animals, subject to regional regulatory approvals.

Basic Information

Product Name	Acrivastine
CAS No.	87848-99-5
Molecular Formula	C22H24N2O2
Molecular Weight	348.44 g/mol
Synonyms	(E)-3-[6-[(E)-1-(4-Methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridin-2-yl]prop-2-enoic acid; BW 825C; Semprex-D; Activastine; Acrivastinum; UNII-6K7P8ZO5XO
EINECS	Contact for details

Quality Control

Our Acrivastine CAS NO 87848-99-5 is manufactured under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH Q7 guidelines for active pharmaceutical ingredients. Comprehensive testing includes HPLC for assay and related substances, residual solvent analysis, and microbiological examination. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Microbial Limits	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.