Description

Cloticasonepropionate is a synthetic corticosteroid propionate ester, a key pharmaceutical intermediate in the development of advanced topical anti-inflammatory and anti-pruritic medications. Its high purity and consistent quality are critical for ensuring the efficacy and safety of the final active pharmaceutical ingredient (API). This compound is primarily required by pharmaceutical R&D laboratories and manufacturing facilities specializing in dermatological corticosteroids, inhalable steroids, and other specialized therapeutic formulations.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of potent corticosteroid APIs for topical and inhaled applications.
• Dermatological Preparations: Used in the research and production of creams, ointments, and lotions for treating eczema, psoriasis, and dermatitis.
• Respiratory Medicine: Serves as a precursor in the manufacture of anti-inflammatory agents for asthma and chronic obstructive pulmonary disease (COPD) inhalers.
• Veterinary Pharmaceuticals: Employed in developing anti-inflammatory treatments for skin conditions in animals.
• Analytical Reference Standard: Provides a high-purity benchmark for quality control and method development in analytical laboratories.
• Process Development & Scale-Up: Supports chemical process optimization and pilot-scale manufacturing for pharmaceutical companies.

Basic Information

Product Name	Cloticasonepropionate
CAS No.	87556-66-9
Molecular Formula	C25H31FO6
Molecular Weight	446.51 g/mol
Synonyms	Cloticasone Propionate; Cloticasone 17-propionate; (6α,11β,16α)-6,9-Difluoro-11,21-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl propionate; 6α,9-Difluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17-propionate; NSC 394000; Cloticasone-17-propanoate
EINECS	Contact for details

Quality Control

Our Cloticasonepropionate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation via IR and NMR spectroscopy, to ensure it meets stringent pharmaceutical intermediate standards. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.