Description

4-Demethoxy-4'-o-Methyldoxorubicin is a chemically modified derivative of the potent anthracycline antibiotic, doxorubicin. This compound is of significant interest in pharmaceutical research and development due to its potential for altered biological activity and reduced cardiotoxicity compared to its parent molecule. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel anticancer agents and the study of structure-activity relationships within the anthracycline class.

Application

• Pharmaceutical Intermediate: Key building block in the research and development of novel anthracycline-based chemotherapeutic agents.
• Oncology Research: Used as a reference standard or active compound in in vitro and in vivo studies to investigate mechanisms of action, efficacy, and toxicity profiles.
• Structure-Activity Relationship (SAR) Studies: Critical for medicinal chemists to understand how specific molecular modifications affect the potency and selectivity of doxorubicin analogs.
• Biochemical Research: Employed in studies targeting DNA intercalation, topoisomerase II inhibition, and other biological pathways relevant to cancer cell proliferation.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	4-Demethoxy-4'-o-Methyldoxorubicin
CAS No.	87471-33-8
Molecular Formula	C₂₇H₂₉NO₁₀
Molecular Weight	527.52 g/mol
Synonyms	4-Demethoxy-4'-O-methyldoxorubicin; 4'-O-Methyl-4-demethoxydoxorubicin; 4'-O-Methyl-4-demethoxyadriamycin; 4-Demethoxy-4'-O-methyladriamycin; ID-6105; NSC 352040; 4-DMDR; 4'-O-Methyl-4-demethoxy-13-dihydrodaunorubicin
EINECS	Contact for details

Quality Control

Our 4-Demethoxy-4'-o-Methyldoxorubicin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all test results against established specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.