Description

9-Amino-6-Trifluoromethylbenzonorbornene is a specialized, high-value organic intermediate featuring a unique norbornene scaffold functionalized with an amino group and a trifluoromethyl substituent. This compound matters for its role as a critical building block in advanced pharmaceutical and agrochemical research, where its rigid, three-dimensional structure and fluorine content are leveraged to modulate biological activity and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, due to its ability to enhance blood-brain barrier penetration and metabolic stability.
• Agrochemical Active Ingredient Synthesis: Used in the development of new-generation herbicides and pesticides, where the trifluoromethyl group contributes to improved efficacy and environmental profile.
• Advanced Material Science: Acts as a monomer or cross-linking agent in the production of specialty polymers, coatings, and resins with unique thermal or chemical resistance properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry for creating novel chiral ligands or catalysts used in asymmetric synthesis.
• Fluorine Chemistry Research: A valuable substrate for studying structure-activity relationships (SAR) and the introduction of fluorine into complex molecular architectures.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring this precise chemical scaffold.

Basic Information

Product Name	9-Amino-6-Trifluoromethylbenzonorbornene
CAS No.	87405-61-6
Molecular Formula	C₁₄H₁₄F₃N
Molecular Weight	253.26 g/mol
Synonyms	9-Amino-6-(trifluoromethyl)benzonorbornene; 6-(Trifluoromethyl)-9-aminobenzonorbornene; 1,4-Methano-1H-indene-7-amine, 2-(trifluoromethyl)-; 2-(Trifluoromethyl)-1,4-methano-1H-indene-7-amine; 9-Amino-6-trifluoromethyl-1,4-methano-1,4-dihydronaphthalene; Bicyclo[2.2.1]hepta-2,5-diene, 2-(trifluoromethyl)-7-amino- (fused benzene derivative)
EINECS	Contact for details

Quality Control

Every batch of 9-Amino-6-Trifluoromethylbenzonorbornene undergoes rigorous analytical testing to ensure it meets the high-purity standards required for research and development applications. Our quality assurance protocol includes identity confirmation, purity assay, and impurity profiling. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at a controlled room temperature (15-25°C). This material is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.