Description

Arotinolol Hydrochloride is a potent, non-selective β-adrenergic receptor antagonist (β-blocker) with intrinsic sympathomimetic activity. This compound is a key active pharmaceutical ingredient (API) valued for its cardiovascular therapeutic effects. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of antihypertensive and antianginal medications.

Application

• Pharmaceutical API: Core active ingredient in the formulation of finished dosage forms for the treatment of hypertension and angina pectoris.
• Cardiovascular Research: A critical reference standard and biochemical tool for studying β-adrenergic receptor mechanisms and cardiovascular pharmacology.
• Drug Development: Used in preclinical and clinical research for developing new therapeutic agents targeting adrenergic pathways.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.
• Generic Drug Manufacturing: Essential for the production of generic versions of arotinolol-based medications, ensuring bioequivalence and therapeutic efficacy.

Basic Information

Product Name	Arotinolol Hydrochloride
CAS No.	87055-50-3
Molecular Formula	C15H21N3O3S•HCl
Molecular Weight	359.87 g/mol
Synonyms	5-[2-[(3-tert-Butylamino-2-hydroxypropyl)thio]-4-thiazolyl]-2-thiophenecarboxamide Hydrochloride; Arotinolol HCl; SM-658; (±)-Arotinolol Hydrochloride; 1-(3-tert-Butylamino-2-hydroxypropylthio)-4-(5-carbamoyl-2-thienyl)thiazole Hydrochloride
EINECS	Contact for details

Quality Control

Our Arotinolol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles. We support compliance with ICH guidelines and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.