Description

3'-o-Acetyl-2-Hydroxyaclacinomycin is a chemically modified derivative of the anthracycline antibiotic aclacinomycin A. This compound is of significant interest in pharmaceutical research and development, particularly as a key intermediate or reference standard in the synthesis of novel chemotherapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on oncology drug discovery and advanced chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel anthracycline-based anticancer agents.
• Biochemical Research: Used as a reference standard or probe in studies investigating the structure-activity relationships (SAR) of DNA-intercalating antibiotics.
• Oncology Drug Discovery: Serves as a precursor for developing new derivatives with potentially improved efficacy or reduced side effects compared to parent compounds.
• Academic Research: Employed in university and institutional labs for mechanistic studies on topoisomerase inhibition and cellular apoptosis pathways.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for producing specialized, high-value chemical entities.
• Analytical Standard: Acts as a high-purity calibrant for quality control and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical settings.

Basic Information

Product Name	3'-o-Acetyl-2-Hydroxyaclacinomycin
CAS No.	86670-20-4
Molecular Formula	C45H55NO18
Molecular Weight	897.92 g/mol
Synonyms	2'-Hydroxyaclacinomycin A 3'-acetate; 3'-O-Acetyl-2'-hydroxyaclacinomycin A; Aclacinomycin A, 3'-O-acetyl-2'-hydroxy-; 2'-Hydroxy-3'-O-acetylaclacinomycin A; Antibiotic MA 144 M1, 3'-O-acetyl-2'-hydroxy-; 3'-Acetyl-2'-hydroxyaclacinomycin A; NSC 354646; 86670-20-4
EINECS	Contact for details

Quality Control

Our 3'-o-Acetyl-2-Hydroxyaclacinomycin is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation and structural verification via spectroscopic methods (NMR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.