Description

Pregna-1,4-Diene-3,20-Dione, 17,21-Bis(Acetyloxy)-11-Hydroxy-6-Methyl-, (6α,11β)- is a high-purity steroid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical pharmaceutical intermediate for the synthesis of potent corticosteroid analogs, where its specific stereochemistry is essential for biological activity. It is primarily required by pharmaceutical manufacturers and contract research organizations (CROs) engaged in the development of novel anti-inflammatory and immunosuppressive therapies.

Application

• Pharmaceutical Intermediate: Key starting material or advanced intermediate in the multi-step synthesis of potent glucocorticoid drugs.
• Active Pharmaceutical Ingredient (API) Development: Used in research for developing new corticosteroid-based APIs targeting inflammation, autoimmune disorders, and allergies.
• Biochemical Research: Serves as a reference standard or probe in steroid receptor binding studies and metabolic pathway research.
• Process Chemistry & Scale-Up: Utilized in process optimization and pilot-scale production for new drug candidates within GMP environments.
• Academic Research: Employed in university and institutional labs for studying steroid chemistry, synthesis methodologies, and structure-activity relationships (SAR).

Basic Information

Product Name	Pregna-1,4-Diene-3,20-Dione, 17,21-Bis(Acetyloxy)-11-Hydroxy-6-Methyl-, (6α,11β)-
CAS No.	86413-24-3
Molecular Formula	C₂₆H₃₄O₇
Molecular Weight	458.55 g/mol
Synonyms	6α-Methylprednisolone 17,21-Diacetate; 6α-Methylprednisolone Diacetate; 11β,17α,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 17,21-diacetate; 6α-Methyl-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-diacetate; U-67590A; (6α,11β)-17,21-Bis(acetyloxy)-11-hydroxy-6-methylpregna-1,4-diene-3,20-dione; Methylprednisolone Diacetate (6α-isomer)
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Diene-3,20-Dione, 17,21-Bis(Acetyloxy)-11-Hydroxy-6-Methyl-, (6α,11β)- is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (IR, NMR), to ensure it meets exacting standards suitable for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.