Description

17-o-Acetyl-6-Methylprednisolone CAS NO 86401-94-7 is a synthetic corticosteroid derivative, specifically an acetylated ester of methylprednisolone. This compound is a critical pharmaceutical intermediate valued for its anti-inflammatory and immunosuppressive properties, which are essential for advanced drug synthesis. It is primarily required by pharmaceutical R&D laboratories and manufacturers developing injectable or topical corticosteroid formulations, as well as by research institutions studying glucocorticoid receptor activity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potent corticosteroid APIs (Active Pharmaceutical Ingredients).
• Anti-inflammatory Drug Research: Used in preclinical and clinical research for developing new treatments for inflammatory and autoimmune conditions.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical manufacturing.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research related to methylprednisolone.
• Formulation Development: Utilized in the development of advanced drug delivery systems, including liposomal and nanoparticle-based therapies.

Basic Information

Product Name	17-o-Acetyl-6-Methylprednisolone
CAS No.	86401-94-7
Molecular Formula	C₂₅H₃₄O₇
Molecular Weight	446.53 g/mol
Synonyms	6α-Methylprednisolone 17-Acetate; 6α-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-acetate; 17α-Acetoxy-6α-methylprednisolone; 6-Methylprednisolone 17-acetate; 17-Acetyl-6-methylprednisolone; Methylprednisolone 17-acetate; 6α-Methylprednisolone 17α-acetate
EINECS	Contact for details

Quality Control

Our 17-o-Acetyl-6-Methylprednisolone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR for identification, and residual solvent analysis, to ensure it meets stringent specifications for pharmaceutical intermediates. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and protected from light exposure to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.