Description

Nafarelin Acetate CAS NO 86220-42-0 is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH) with potent agonist activity. This compound is critical for its ability to initially stimulate and then downregulate pituitary gonadotropin secretion, making it a valuable active pharmaceutical ingredient (API). It is primarily required by the pharmaceutical industry for the formulation of treatments in reproductive medicine and oncology, such as for central precocious puberty, endometriosis, and prostate cancer.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable formulations for hormone-dependent therapies.
• Endometriosis Treatment: Key component in nasal spray formulations used to manage pain and symptoms associated with endometriosis.
• Central Precocious Puberty (CPP): Used in therapeutic regimens to delay early onset puberty in children.
• Prostate Cancer Therapy: Employed in androgen deprivation therapy to manage advanced prostate cancer.
• Uterine Fibroids Management: Used preoperatively to reduce fibroid size and control bleeding.
• Assisted Reproductive Technology (ART): Utilized in controlled ovarian hyperstimulation protocols.
• Research & Development: Serves as a reference standard and key reagent in endocrine and oncology research.
• Veterinary Pharmaceuticals: Applied in fertility control and treatment of hormone-related conditions in animals.

Basic Information

Product Name	Nafarelin Acetate
CAS No.	86220-42-0
Molecular Formula	C66H83N17O13 • (C2H4O2)n
Molecular Weight	1322.5 g/mol (free base)
Synonyms	Nafarelin; Nafarelin Acetate Salt; (D-Nal(2)6)-LHRH; Gonadorelin (6-D-2-Naphthylalanine) Acetate; LHRH Agonist (D-Nal(2)6); RS-94991; SYNAREL (Brand Name); 5-Oxo-Pro-His-Trp-Ser-Tyr-D-Nal(2)-Leu-Arg-Pro-Gly-NH2 Acetate
EINECS	Contact for details

Quality Control

Our Nafarelin Acetate is manufactured under strict quality systems to ensure it meets the rigorous standards required for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, determination of related substances, residual solvents, and specific tests for identity and content. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, confirming compliance with in-house specifications aligned with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F), or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Acetic Acid Content	5.0% - 12.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 10.0 EU/mg
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.