Description

9-Chloro-11Beta,17-Dihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21(Trans)-[4-(Acetamidomethyl)Cyclohexane-1-Carboxylate] is a high-purity synthetic steroid derivative, specifically engineered for advanced pharmaceutical research and development. This compound is valued for its role as a key intermediate in the synthesis of potent glucocorticoid receptor modulators, offering researchers a critical building block for creating novel therapeutic agents. It is primarily sought by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic institutions focused on endocrinology, inflammation, and metabolic disease research.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of advanced corticosteroid analogs and novel glucocorticoids.
• Active Pharmaceutical Ingredient (API) Development: Used in research for developing new anti-inflammatory and immunosuppressive drug candidates.
• Biochemical Research: Employed as a reference standard or ligand in studies investigating glucocorticoid receptor binding affinity and function.
• Process Chemistry & Scale-Up: A key material for process optimization and pilot-scale production runs in regulated environments.
• Academic Research: Utilized in university and institutional labs for studying steroid chemistry, structure-activity relationships (SAR), and metabolic pathways.

Basic Information

Product Name	9-Chloro-11Beta,17-Dihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21(Trans)-[4-(Acetamidomethyl)Cyclohexane-1-Carboxylate]
CAS No.	86022-88-0
Molecular Formula	C₃₂H₄₂ClNO₇
Molecular Weight	588.13 g/mol
Synonyms	9-Chloro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-trans-[4-(acetamidomethyl)cyclohexanecarboxylate]; 21-(4-(Acetamidomethyl)cyclohexanecarboxyl)-9-chloro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione; Loteprednol Etabonate Intermediate; Chlorinated Prednisolone Derivative; LE Intermediate; Corticosteroid Ester Intermediate; 86022-88-0; UNII-Contact for details
EINECS	Contact for details

Quality Control

Our 9-Chloro-11Beta,17-Dihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21(Trans)-[4-(Acetamidomethyl)Cyclohexane-1-Carboxylate] is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions to maintain stability and purity. For long-term storage, consider using a desiccator or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.