Description

Methyl 4,4,4-Trifluorocrotonate is a versatile fluorinated building block and a key intermediate in advanced organic synthesis. Its value lies in the introduction of the trifluoromethyl group and the reactive α,β-unsaturated ester moiety, enabling the construction of complex molecules with enhanced properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs) containing trifluoromethyl groups, which can improve metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science: Serves as a monomer or precursor for fluorinated polymers and advanced materials with unique surface properties, chemical resistance, and thermal stability.
• Organic Synthesis Reagent: Employed in Michael addition reactions, cycloadditions, and other C-C bond-forming transformations to create complex molecular architectures.
• Liquid Crystal & Electronic Chemical Intermediate: Used in the synthesis of fluorinated components for liquid crystal displays (LCDs) and electronic materials.

Basic Information

Product Name	Methyl 4,4,4-Trifluorocrotonate
CAS No.	85694-31-1
Molecular Formula	C5H5F3O2
Molecular Weight	154.09 g/mol
Synonyms	Methyl 4,4,4-Trifluorobut-2-enoate; 4,4,4-Trifluorocrotonic Acid Methyl Ester; 2-Butenoic acid, 4,4,4-trifluoro-, methyl ester; Methyl (E)-4,4,4-trifluorocrotonate; Trifluorocrotonic acid methyl ester; Methyl β,β,β-trifluorocrotonate
EINECS	Contact for details

Quality Control

Our Methyl 4,4,4-Trifluorocrotonate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing key specifications and test results. Our quality commitment supports compliance with ISO standards and the requirements of cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong acids, bases, and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.