Description

Tilisolol CAS NO 85136-71-6 is a selective β-1 adrenergic receptor antagonist (β-blocker) used in pharmaceutical research and development. This compound is of significant interest for its potential cardiovascular applications, particularly in the study of hypertension and angina. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in preclinical studies and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced β-blocker drug candidates and related cardiovascular agents.
• Preclinical Research: Used in in vitro and in vivo studies to investigate β-1 adrenergic receptor pharmacology, selectivity, and mechanism of action.
• Reference Standard: Employed as an analytical standard in method development and quality control (QC) for drug substance and product analysis.
• Metabolite Studies: Utilized in the identification and characterization of drug metabolites during ADME (Absorption, Distribution, Metabolism, and Excretion) profiling.
• Formulation Development: Aids in the development and stability testing of dosage forms containing β-adrenergic blocking agents.

Basic Information

Product Name	Tilisolol
CAS No.	85136-71-6
Molecular Formula	C17H28N2O4S
Molecular Weight	356.48 g/mol
Synonyms	1-(tert-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol; Tilisolol Hydrochloride (salt form); K-351; B-351; (±)-Tilisolol; 1-(tert-Butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
EINECS	Contact for details

Quality Control

Our Tilisolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, HPLC), assay (HPLC), and impurity profiling to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.