Description

9-Deoxydoxorubicin is a structural analog of the potent anthracycline antibiotic doxorubicin, characterized by the absence of the 9-hydroxyl group. This modification is of significant interest in pharmaceutical research for exploring structure-activity relationships and developing novel chemotherapeutic agents with potentially altered efficacy and toxicity profiles. It serves as a critical pharmaceutical intermediate and reference standard for researchers in oncology, medicinal chemistry, and pharmacology.

Application

• Pharmaceutical Intermediate: Key building block in the research and development of novel anthracycline-based anticancer drugs.
• Medicinal Chemistry Research: Used to study the impact of structural modifications on the biological activity, pharmacokinetics, and cardiotoxicity of doxorubicin analogs.
• Biochemical Research: Employed as a tool compound to investigate mechanisms of action involving topoisomerase II inhibition and DNA intercalation.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis (HPLC, LC-MS).
• Academic & Institutional Research: Utilized in universities and research institutes for preclinical studies and target validation.

Basic Information

Product Name	9-Deoxydoxorubicin
CAS No.	84519-42-6
Molecular Formula	C27H29NO10
Molecular Weight	527.52 g/mol
Synonyms	9-Deoxyadriamycin; 9-Deoxydoxorubicin Hydrochloride; 9-DOA; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; NSC 321421; Doxorubicin, 9-deoxy-
EINECS	Contact for details

Quality Control

We supply 9-Deoxydoxorubicin in high-purity grades suitable for research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is accompanied by comprehensive analytical data, including HPLC purity, identity confirmation (IR, MS), and impurity profiling. Certificates of Analysis (COA) are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥95.0% (Area %)
Water Content (KF)	≤5.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.