Description

Cetirizine Amide CAS NO 83881-37-2 is a key pharmaceutical intermediate in the synthesis of Cetirizine, a widely used second-generation antihistamine. This high-purity compound is critical for ensuring the efficacy, safety, and batch-to-batch consistency of the final active pharmaceutical ingredient (API). It is primarily required by manufacturers in the pharmaceutical and fine chemical industries engaged in the production of antihistamine medications and advanced chemical research.

Application

• Primary Intermediate in the commercial synthesis of Cetirizine Dihydrochloride API.
• Research & Development for novel antihistamine derivatives and related therapeutic agents.
• Process Chemistry optimization and scale-up studies within pharmaceutical manufacturing.
• Reference Standard for quality control and analytical method development in API production.
• Fine Chemical Synthesis for building more complex molecules in medicinal chemistry.

Basic Information

Product Name	Cetirizine Amide
CAS No.	83881-37-2
Molecular Formula	C21H25ClN2O3
Molecular Weight	388.89 g/mol
Synonyms	2-[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetamide; [2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetamide; Cetirizine Amide Intermediate; Cetirizine Precursor; Zyrtec Amide Intermediate; UCB-P071 Amide
EINECS	Contact for details

Quality Control

Our Cetirizine Amide is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical intermediates. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) documenting full specifications are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The material is hygroscopic (moisture-sensitive); keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.