Description

21-Chloro-9-Beta,11-β-Epoxy-17-Hydroxy-16-α-Methylpregna-1,4-Diene-3,20-Dione is a high-purity, synthetic steroid derivative with a complex molecular architecture, serving as a critical advanced intermediate in pharmaceutical synthesis. Its value lies in providing a precise and reliable chemical backbone for the research and development of novel therapeutic agents, particularly corticosteroids. This compound is essential for pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on steroid chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent glucocorticoid and anti-inflammatory steroid APIs.
• Research & Development: Used in medicinal chemistry programs to explore new derivatives and analogs with modified biological activity profiles.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and optimization studies for the industrial production of steroid-based drugs.
• Biochemical Research: Utilized in studies investigating steroid hormone receptor interactions and metabolic pathways.

Basic Information

Product Name	21-Chloro-9-Beta,11-β-Epoxy-17-Hydroxy-16-α-Methylpregna-1,4-Diene-3,20-Dione
CAS No.	83881-08-7
Molecular Formula	C22H25ClO5
Molecular Weight	404.88 g/mol
Synonyms	9β,11β-Epoxy-21-chloro-17-hydroxy-16α-methylpregna-1,4-diene-3,20-dione; 21-Chloro-9β,11β-epoxy-17-hydroxy-16α-methylpregna-1,4-diene-3,20-dione; 16α-Methyl-9β,11β-epoxy-21-chloropregna-1,4-diene-3,20-dione-17-ol; Betamethasone 17,21-Dichlorohydrin 9,11-Epoxide; 21-Chloro-9,11-epoxy-16-methylpregna-1,4-diene-3,20-dione-17-ol
EINECS	Contact for details

Quality Control

Our 21-Chloro-9-Beta,11-β-Epoxy-17-Hydroxy-16-α-Methylpregna-1,4-Diene-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.