Description

Droloxifene Hcl CAS NO 83647-28-3 is a high-purity pharmaceutical intermediate and research chemical belonging to the selective estrogen receptor modulator (SERM) class. It is a critical compound for the development and production of advanced therapeutic agents targeting hormone-related conditions. This product is essential for pharmaceutical manufacturers, research institutions, and biotechnology companies engaged in oncology research, drug discovery, and the synthesis of novel therapeutic entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced SERM-based active pharmaceutical ingredients (APIs).
• Oncology Research: Used in preclinical and clinical research for studying breast cancer treatment mechanisms and developing new anti-estrogen therapies.
• Biochemical Research: Serves as a reference standard and tool compound for investigating estrogen receptor biology and signal transduction pathways.
• Drug Discovery & Development: Utilized in high-throughput screening and medicinal chemistry programs to develop new selective estrogen receptor modulators.
• Academic Research: Employed in university and institutional labs for pharmacological studies and endocrine system research.
• GMP Manufacturing: Supplied as a starting material or intermediate for the production of pharmaceuticals under Good Manufacturing Practice (GMP) guidelines.

Basic Information

Product Name	Droloxifene Hcl
CAS No.	83647-28-3
Molecular Formula	C26H29NO2•HCl
Molecular Weight	415.98 g/mol
Synonyms	3-Hydroxytamoxifen Hydrochloride; Droloxifene Hydrochloride; (Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1,2-diphenyl-1-butene Hydrochloride; K 21060E; K-21060.E; 3-OHTAM Hydrochloride; 3-Hydroxy Tamoxifen HCl
EINECS	Contact for details

Quality Control

Our Droloxifene Hcl is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Quality is verified through comprehensive analytical testing including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch. We support development projects with material that can meet GMP and ICH guideline requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.