Description

Iodocyanopindolol CAS NO 83498-72-0 is a high-purity, non-selective β-adrenergic receptor antagonist (β-blocker) derivative, primarily used as a potent radioligand in pharmacological research. Its core value lies in its high affinity and specificity for β-adrenergic receptors, making it an indispensable tool for receptor binding assays and molecular pharmacology studies. This compound is critically needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in cardiovascular research, neuropharmacology, and drug discovery programs.

Application

• Radioligand in Receptor Binding Assays: Primary use as a labeled tracer (e.g., [125I]-iodocyanopindolol) for the quantification and characterization of β-adrenergic receptors in tissue homogenates and cell membranes.
• Pharmacological Research: Used to study the affinity, density, and distribution of β-1 and β-2 adrenergic receptors in various biological systems.
• Drug Discovery & Development: Serves as a key reference standard and competitor in high-throughput screening (HTS) to identify and evaluate novel β-blockers or adrenergic compounds.
• Cardiovascular & Metabolic Disease Studies: Applied in research models investigating heart failure, hypertension, and metabolic syndromes where adrenergic signaling is implicated.
• Neuropharmacology: Utilized in central nervous system research to explore the role of β-adrenergic receptors in neurological functions and disorders.
• Biomarker Research: Potential use in developing diagnostic assays for conditions associated with altered adrenergic receptor expression.

Basic Information

Product Name	Iodocyanopindolol
CAS No.	83498-72-0
Molecular Formula	C20H22IN3O2
Molecular Weight	487.32 g/mol
Synonyms	1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol 3-Iodocyanopindolol; (±)-Iodocyanopindolol; Iodocyanopindolol; 4-[3-[(2S)-2-Hydroxy-3-(propan-2-ylamino)propoxy]indol-1-yl]benzonitrile; I-CYP; ICYP; Cyanopindolol Iodide Derivative
EINECS	Contact for details

Quality Control

Our Iodocyanopindolol is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent internal specifications. We support research requiring traceable and reliable reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under an inert atmosphere to maintain stability. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.