Description

14-Dodecyl-14-Thiaadriamycin is a chemically modified derivative of the anthracycline class, designed to enhance specific pharmacological properties. This compound is valued for its potential in advanced research and development, particularly in exploring novel mechanisms of action. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and specialty chemical manufacturers focused on oncology and antimicrobial discovery.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or active compound in the discovery of new anticancer and antimicrobial agents.
• Biochemical Studies: Used to investigate structure-activity relationships (SAR) and mechanisms of DNA intercalation and topoisomerase II inhibition.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Preclinical Studies: Utilized in in vitro and in vivo models to evaluate efficacy, toxicity, and pharmacokinetic profiles of novel anthracycline derivatives.
• Specialty Chemical Synthesis: Acts as a sophisticated building block for the synthesis of more complex, targeted therapeutic molecules.

Basic Information

Product Name	14-Dodecyl-14-Thiaadriamycin
CAS No.	83291-66-1
Molecular Formula	C41H61NO12S
Molecular Weight	792.0 g/mol
Synonyms	14-Dodecylthiaadriamycin; 14-Dodecyl-14-thia-adriamycin; 14-Thia-14-dodecyl-adriamycin; AD 143; NSC 356894; 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-14-dodecyl-14-thia-; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-14-dodecyl-14-thia-5,12-naphthacenedione
EINECS	Contact for details

Quality Control

Our 14-Dodecyl-14-Thiaadriamycin is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research applications. Quality is verified through advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.