Description

(±)-Bunitrolol CAS NO 83073-79-4 is a non-selective β-adrenergic receptor antagonist (β-blocker) of significant interest in pharmaceutical research and development. This compound serves as a critical intermediate and reference standard for the synthesis and analytical characterization of active pharmaceutical ingredients (APIs) targeting cardiovascular conditions. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions focused on cardiology and drug discovery.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of β-blocker APIs and related derivatives.
• Reference Standard: Used for method development, validation, and quality control (QC) in analytical laboratories (HPLC, GC, LC-MS).
• Biochemical Research: Tool compound for studying β-adrenergic receptor pharmacology, binding affinity, and signal transduction pathways.
• Preclinical Studies: Employed in in vitro and in vivo research models to investigate cardiovascular effects and pharmacokinetics.
• Impurity Standard: Serves as a certified reference material (CRM) for identifying and quantifying related substances in final drug products.
• Process Development: Used in scaling up and optimizing synthetic routes within process chemistry.

Basic Information

Product Name	(±)-Bunitrolol
CAS No.	83073-79-4
Molecular Formula	C17H20N2O3
Molecular Weight	300.36 g/mol
Synonyms	Bunitrolol; (±)-Bunitrolol; DL-Bunitrolol; 2-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]benzonitrile; 1-(tert-Butylamino)-3-(o-cyanophenoxy)-2-propanol; Ko 1366; Bunitrololum
EINECS	Contact for details

Quality Control

Our (±)-Bunitrolol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and development use. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.