Description

7-(2,3-Epoxypropoxy)Actinomycin D is a chemically modified derivative of the potent antitumor antibiotic, Actinomycin D, featuring an epoxypropoxy functional group. This modification is strategically designed to enhance its utility as a key intermediate or active moiety in the development of targeted cancer therapeutics and advanced pharmaceutical research. It is primarily sought by research institutions and pharmaceutical companies engaged in oncology drug discovery, bioconjugation studies, and the synthesis of novel antibody-drug conjugates (ADCs).

Application

• Antibody-Drug Conjugate (ADC) Payload Synthesis: Serves as a cytotoxic warhead for conjugation to monoclonal antibodies targeting specific cancer cells.
• Oncology Research & Drug Discovery: Used as a biochemical tool to study DNA intercalation mechanisms and to develop novel chemotherapeutic agents.
• Bioconjugation & Prodrug Development: The reactive epoxy group enables covalent linkage to various carriers, peptides, or polymers for targeted delivery systems.
• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of advanced experimental anticancer compounds.
• Biochemical Mechanism Studies: Employed in research to investigate the impact of structural modifications on the biological activity and selectivity of actinomycin derivatives.

Basic Information

Product Name	7-(2,3-Epoxypropoxy)Actinomycin D
CAS No.	82830-18-0
Molecular Formula	C63H86N12O17
Molecular Weight	1283.44 g/mol
Synonyms	Actinomycin D, 7-(2,3-epoxypropoxy)-; 7-O-(2,3-Epoxypropyl)actinomycin D; NSC 330836; Actinomycin D epoxypropyl ether; 2,3-Epoxypropyl actinomycin D ether; Actinomycin D derivative, epoxypropoxy-
EINECS	Contact for details

Quality Control

Every batch of 7-(2,3-Epoxypropoxy)Actinomycin D is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency suitable for research and development applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store unopened vials at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. For short-term use, the material may be stored at 2-8°C. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Red-orange to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.