Description

Pregn-4-Ene-3,20-Dione, 21-Chloro-9,11-Epoxy-16,17-[(1-Methylethylidene)Bis(Oxy)]-, (9β,11β,16α)- is a high-purity, complex steroid derivative with significant synthetic utility. This compound is valued for its role as a critical advanced intermediate in the multi-step synthesis of potent, modern glucocorticoid and anti-inflammatory pharmaceutical agents. It is primarily required by research institutions, custom synthesis houses, and pharmaceutical manufacturers engaged in the development and production of novel steroid-based therapeutics. The compound, identified by CAS No. 82427-96-1, demands expert handling and a reliable supply chain to ensure consistency in downstream API manufacturing.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel glucocorticoid receptor agonists and other steroidal drugs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new anti-inflammatory compounds.
• Custom Synthesis: Serves as a starting material or intermediate for contract research organizations (CROs) and CDMOs producing specialized steroid APIs.
• Process Chemistry: Employed in the development and scale-up of optimized synthetic routes for complex steroid molecules.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Pregn-4-Ene-3,20-Dione, 21-Chloro-9,11-Epoxy-16,17-[(1-Methylethylidene)Bis(Oxy)]-, (9β,11β,16α)-
CAS No.	82427-96-1
Molecular Formula	C24H31ClO5
Molecular Weight	434.96 g/mol
Synonyms	21-Chloro-9β,11β-epoxy-16α,17α-isopropylidenedioxypregn-4-ene-3,20-dione; 21-Chloro-9β,11β-epoxy-16α,17α-(isopropylidenedioxy)pregn-4-ene-3,20-dione; 9β,11β-Epoxy-21-chloro-16α,17α-isopropylidenedioxypregn-4-ene-3,20-dione; (9β,11β,16α)-21-Chloro-9,11-epoxy-16,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione; Steroid Intermediate 82427-96-1; 21-Chloro-16α,17α-acetonide-9β,11β-epoxypregn-4-ene-3,20-dione
EINECS	Contact for details

Quality Control

Our production of this advanced steroid intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical synthesis. Quality is verified through comprehensive analytical techniques including HPLC, GC, and NMR to confirm identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications. We support compliance with ICH guidelines for impurities and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.