Description

4Hydroxy Tamoxifen is a major active metabolite of the selective estrogen receptor modulator (SERM) Tamoxifen. This compound is critical for advanced pharmaceutical research and development, particularly in the study of breast cancer therapeutics and endocrine signaling pathways. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in oncology drug discovery, metabolite profiling, and biochemical assay development.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quality control and assay validation of Tamoxifen and its related drug products.
• Biochemical Research: Used as a potent tool compound in vitro to study estrogen receptor (ER) antagonism, gene expression regulation, and cellular apoptosis mechanisms.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the metabolism, bioavailability, and activity profile of Tamoxifen.
• Drug Discovery & Development: Acts as a key intermediate or active pharmaceutical ingredient (API) in the development of novel SERMs and targeted cancer therapies.
• Diagnostic Kit Manufacturing: Employed in the production of calibration standards for diagnostic assays measuring Tamoxifen and its metabolites in patient samples.

Basic Information

Product Name	4Hydroxy Tamoxifen
CAS No.	82413-23-8
Molecular Formula	C26H29NO2
Molecular Weight	387.52 g/mol
Synonyms	4-Hydroxytamoxifen; (Z)-4-Hydroxytamoxifen; Afimoxifene; Metabolite E; ICI 79280; Endoxifen; (Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1,2-diphenyl-1-buten-4-ol; 4-OHT
EINECS	Contact for details

Quality Control

Our 4Hydroxy Tamoxifen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.