Description

Droloxifene CAS NO 82413-20-5 is a selective estrogen receptor modulator (SERM) known for its high binding affinity and tissue-specific activity. This compound is a critical intermediate in pharmaceutical research and development, particularly for investigating novel therapeutic agents targeting hormone-dependent conditions. It is primarily utilized by pharmaceutical manufacturers, research institutions, and contract development organizations engaged in oncology, endocrinology, and women's health.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced SERM-based drug candidates.
• Biomedical Research: Used as a reference standard and active agent in preclinical studies for breast cancer and osteoporosis.
• Mechanistic Studies: Employed to study estrogen receptor alpha (ERα) and beta (ERβ) signaling pathways and receptor-ligand interactions.
• Analytical Standard: Serves as a high-purity standard for method development and validation in quality control laboratories (HPLC, LC-MS).
• Comparative Pharmacology: Used in research to compare efficacy and selectivity profiles against other SERMs like tamoxifen and raloxifene.

Basic Information

Product Name	Droloxifene
CAS No.	82413-20-5
Molecular Formula	C29H35NO2
Molecular Weight	429.60 g/mol
Synonyms	3-Hydroxytamoxifen; K 21060-E; (Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1,2-diphenyl-1-buten-3-ol; 3-OH-Tamoxifen; 3-Hydroxy Tamoxifen; Droloxifene Citrate (salt form); Droloxifen
EINECS	Contact for details

Quality Control

Our Droloxifene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the stringent requirements for pharmaceutical research. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.