Description

1,2-Dihydro Diethyl Loteprednol Carbonate is a key pharmaceutical intermediate in the synthesis of loteprednol etabonate, a potent corticosteroid. This compound matters for its role in producing a critical active pharmaceutical ingredient (API) with high purity and efficacy. It is primarily needed by pharmaceutical manufacturers and R&D organizations focused on developing and producing ophthalmic anti-inflammatory medications.

Application

• Primary Intermediate in the synthesis of Loteprednol Etabonate API.
• Pharmaceutical Research & Development for novel corticosteroid formulations.
• Active Pharmaceutical Ingredient (API) Manufacturing for ophthalmic solutions and suspensions.
• Production of Anti-inflammatory Drugs targeting allergic conjunctivitis and post-operative inflammation.
• Reference Standard for quality control and analytical method development in pharmaceutical labs.
• Process Chemistry for scaling up and optimizing loteprednol production.

Basic Information

Product Name	1,2-Dihydro Diethyl Loteprednol Carbonate
CAS No.	82048-81-5
Molecular Formula	C₂₄H₃₂O₇
Molecular Weight	432.51 g/mol
Synonyms	Diethyl 1,2-Dihydro Loteprednol Carbonate; 1,2-Dihydro Loteprednol Diethyl Carbonate; Loteprednol Diethyl Carbonate Intermediate; Chloromethyl 17α-[(ethoxycarbonyl)oxy]-11β-hydroxy-3-oxoandrosta-1,4-diene-17β-carboxylate; 11β,17-Dihydroxy-21-(2-chloroacetyl)-17-(ethoxycarbonyl)pregna-1,4-diene-3,20-dione 1,2-Dihydro Derivative; PM-94 Intermediate; LE-Diethyl Carbonate
EINECS	Contact for details

Quality Control

Our 1,2-Dihydro Diethyl Loteprednol Carbonate is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.