Description

Hydrocortisone, 11,21-Diacetate is a key pharmaceutical intermediate and a diacetylated derivative of the natural glucocorticoid hydrocortisone. This modification enhances its stability and alters its pharmacokinetic profile, making it a valuable precursor in the synthesis of more complex steroid-based active pharmaceutical ingredients (APIs). It is primarily required by manufacturers in the pharmaceutical and life sciences sectors for the development and production of corticosteroid medications, anti-inflammatory agents, and for advanced research in endocrinology.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of more potent topical and systemic corticosteroid drugs.
• Anti-inflammatory Agent Research: Used in preclinical and formulation research to study the effects of corticosteroid derivatives.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for quality control and analytical method development in pharmaceutical laboratories.
• API Synthesis: Employed in the production of specific steroid-based Active Pharmaceutical Ingredients where the diacetate group is a required protective or functional moiety.
• Biochemical Research: Utilized in studies investigating glucocorticoid receptor interactions, metabolic pathways, and steroid hormone chemistry.

Basic Information

Product Name	Hydrocortisone, 11,21-Diacetate
CAS No.	81968-66-3
Molecular Formula	C₂₅H₃₄O₇
Molecular Weight	446.53 g/mol
Synonyms	Cortisol 21-acetate 11-acetate; Hydrocortisone diacetate; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 11,21-diacetate; Cortisol diacetate; NSC 113935; 11β,17,21-Trihydroxypregn-4-ene-3,20-dione 11,21-diacetate; 21-Acetyloxy-11β,17-dihydroxypregn-4-ene-3,20-dione 11-acetate
EINECS	Contact for details

Quality Control

Our Hydrocortisone, 11,21-Diacetate is manufactured and tested to meet high-purity standards suitable for pharmaceutical R&D and intermediate use. Quality is assured through rigorous analytical controls including HPLC, IR, and NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to ensure traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.