Description

4-Hydroxypenbutolol is a key pharmaceutical intermediate and reference standard, identified by CAS NO 81542-82-7. This compound is of significant importance in the research, development, and quality control of cardiovascular and β-blocker medications. It is primarily required by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in drug synthesis and impurity profiling. Our supply ensures high purity and batch-to-batch consistency for critical applications.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced β-adrenergic blocking agents (β-blockers).
• Reference Standard: Used as a certified standard for analytical method development, validation, and quality control (QC/QA) in pharmaceutical labs.
• Impurity Standard: Essential for the identification and quantification of related substances and degradation products in penbutolol and similar drug substances.
• Metabolite Studies: Employed in pharmacological and pharmacokinetic research to study the metabolism and biological activity of penbutolol.
• Research & Development: Serves as a key reagent in medicinal chemistry for the design and synthesis of new therapeutic compounds targeting cardiovascular diseases.

Basic Information

Product Name	4-Hydroxypenbutolol
CAS No.	81542-82-7
Molecular Formula	C18H31NO3
Molecular Weight	309.45 g/mol
Synonyms	1-(tert-Butylamino)-3-[(2S)-2-hydroxy-3-(2-cyclopentylphenoxy)propyl]amino]-2-propanol; Penbutolol Hydroxy Metabolite; 4'-Hydroxy Penbutolol; (S)-1-(tert-Butylamino)-3-[(2-hydroxy-3-(o-cyclopentylphenoxy)propyl]amino]-2-propanol; (±)-4'-Hydroxypenbutolol; 81542-82-7; HO-Penbutolol
EINECS	Contact for details

Quality Control

Our 4-Hydroxypenbutolol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.