Description

2-Hydroxy-5-(Trifluoromethyl) Benzonitrile is a versatile aromatic nitrile derivative characterized by a hydroxyl group and a trifluoromethyl substituent on the benzene ring. This unique molecular structure makes it a valuable high-purity building block for advanced organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring a trifluoromethylated phenol or benzonitrile moiety.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the CF3 group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and polymers with specific optical or electronic properties.
• Fluorine Chemistry Studies: An important compound for investigating structure-activity relationships (SAR) in fluorine-containing molecules.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	2-Hydroxy-5-(Trifluoromethyl) Benzonitrile
CAS No.	81465-88-5
Molecular Formula	C8H4F3NO
Molecular Weight	187.12 g/mol
Synonyms	5-(Trifluoromethyl)-2-hydroxybenzonitrile; 2-Cyano-4-(trifluoromethyl)phenol; 4-(Trifluoromethyl)salicylonitrile; 2-Hydroxy-α,α,α-trifluoro-p-tolunitrile; 5-(Trifluoromethyl)salicylonitrile; Phenol, 2-cyano-4-(trifluoromethyl)-; Benzonitrile, 2-hydroxy-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-Hydroxy-5-(Trifluoromethyl) Benzonitrile is manufactured under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, GC, NMR, and FTIR analysis, to ensure compliance with exacting purity standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.