Description

25-Dihydrosaframycin A is a key synthetic intermediate and reference standard derived from the saframycin family of potent antitumor antibiotics. This compound is of significant value in pharmaceutical research and development, particularly for studying structure-activity relationships and metabolic pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology drug discovery and the synthesis of novel bioactive compounds.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of saframycin analogs in research and quality control laboratories.
• Oncology Research Intermediate: Serves as a critical building block in the synthesis of novel antitumor agents and for probing biological mechanisms.
• Biochemical Research: Employed in studies investigating DNA interaction, topoisomerase inhibition, and apoptosis induction.
• Metabolite Studies: Utilized as a standard in pharmacokinetic and metabolic stability studies of saframycin-class drugs.
• Process Chemistry: Acts as an intermediate in the scale-up and optimization of synthetic routes for complex natural product derivatives.

Basic Information

Item	Detail
Product Name	25-Dihydrosaframycin A
CAS No.	81382-09-4
Molecular Formula	C₂₈H₃₃N₃O₇
Molecular Weight	523.58 g/mol
Synonyms	25-Dihydro Saframycin A; 25-Dihydrosaframycin A; Saframycin A, 25-dihydro-; NSC 339638; 1,2,3,4,6,7,12,12b-Octahydro-9,10-dimethoxy-2-methyl-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-6-carboxylic acid methyl ester; (12bS)-1,2,3,4,6,7,12,12b-Octahydro-9,10-dimethoxy-2-methyl-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-6-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 25-Dihydrosaframycin A is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label or COA. This product is light-sensitive and easily oxidized; prolonged exposure to air or light should be avoided.

Specification

Item	Specification
Appearance	Yellow to brown powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.