Description

5,12-Naphthacenedione, 10-(3-Amino-2,3,6-Trideoxy-.Alpha.-L-Lyxo-Hexopyranosyl)Oxy-7,8,9,10-Tetrahydro-1,8,11-Trihydroxy-8-(Hydroxyacetyl)-, (8S,10S)- is a complex glycosylated anthracycline derivative with significant biological activity. This compound is valued for its role as a key intermediate or reference standard in advanced pharmaceutical research and development. It is primarily needed by research institutions and pharmaceutical companies focused on oncology, antibiotic discovery, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Critical building block in the synthetic pathway of novel anthracycline-based chemotherapeutic agents.
• Biochemical Research: Used as a reference standard or probe in studies investigating DNA intercalation, topoisomerase inhibition, and mechanisms of antibiotic action.
• Anticancer Drug Development: Serves as a precursor or analog in the research and development of new oncology treatments targeting specific cancer cell pathways.
• Antibiotic Research: Employed in the synthesis and study of next-generation glycosylated antibiotics to combat resistant bacterial strains.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development and structure-activity relationship (SAR) studies.

Basic Information

Product Name	5,12-Naphthacenedione, 10-(3-Amino-2,3,6-Trideoxy-.Alpha.-L-Lyxo-Hexopyranosyl)Oxy-7,8,9,10-Tetrahydro-1,8,11-Trihydroxy-8-(Hydroxyacetyl)-, (8S,10S)-
CAS No.	81382-05-0
Molecular Formula	C27H31NO12
Molecular Weight	561.54 g/mol
Synonyms	10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione; Aclacinomycin A Hydroquinone; Aclarubicin Hydroquinone; Aclacinomycin Hydroquinone; Antibiotic MA 144 M1 Hydroquinone; (8S,10S)-8-(Hydroxyacetyl)-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,8,11-trihydroxy-5,12-naphthacenedione
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material suitable for research and development purposes, with typical purity levels meeting or exceeding 95% (by HPLC). Certificates of Analysis (COA) detailing identity, purity, and related substance profiles are available upon request. Production can be aligned with cGMP guidelines for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, desiccate to maintain stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Reddish-brown to orange solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.