Description

Ethyl 3-[3-Fluoro-4-[2-Hydroxy-3-(Propan-2-Ylamino)Propoxy]Phenyl]Propanoate Hydrochloride is a high-purity, non-racemic chiral building block and a key pharmaceutical intermediate. Its value lies in its role as a precursor in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly β-adrenergic blocking agents. This compound is essential for research institutions and pharmaceutical manufacturers engaged in the development and production of cardiovascular and ophthalmic medications.

Application

• Pharmaceutical Intermediate: Primary use as a critical chiral synthon in the multi-step synthesis of β-blocker APIs.
• Active Pharmaceutical Ingredient (API) Development: Serves as a key precursor in R&D for novel cardiovascular and anti-glaucoma drugs.
• Chemical Research: Used in academic and industrial laboratories for studying structure-activity relationships (SAR) of adrenergic compounds.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes and scaling production from laboratory to pilot plant and commercial manufacturing.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API production.

Basic Information

Product Name	Ethyl 3-[3-Fluoro-4-[2-Hydroxy-3-(Propan-2-Ylamino)Propoxy]Phenyl]Propanoate Hydrochloride
CAS No.	81148-29-0
Molecular Formula	C17H27ClFNO4
Molecular Weight	363.85 g/mol
Synonyms	Ethyl 3-(3-Fluoro-4-{[2-hydroxy-3-(isopropylamino)propyl]oxy}phenyl)propanoate hydrochloride; (R,S)-Ethyl 3-[3-Fluoro-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]propanoate hydrochloride; Betaxolol Impurity; Betaxolol Related Compound; Betaxolol Intermediate; 1-[4-[2-(Carbethoxy)ethyl]-2-fluorophenoxy]-3-(isopropylamino)-2-propanol hydrochloride; 3-Fluoro-4-[2-hydroxy-3-(isopropylamino)propoxy]hydrocinnamic acid ethyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our Ethyl 3-[3-Fluoro-4-[2-Hydroxy-3-(Propan-2-Ylamino)Propoxy]Phenyl]Propanoate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (or as specified)
Related Substances (HPLC)	Individual unknown impurity ≤0.5% Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.