Description

Ethyl 3-[4-[2-Hydroxy-3-(Propan-2-Ylamino)Propoxy]Phenyl]Propanoate is a high-purity synthetic intermediate of significant importance in advanced pharmaceutical research and development. This compound is valued for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting cardiovascular and neurological pathways. It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and fine chemical producers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of β-adrenergic blocking agents (β-blockers) and related cardiovascular drugs.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a key chiral building block for the production of complex, high-value APIs requiring specific stereochemistry.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new drug candidates.
• Fine Chemical Production: Employed in custom synthesis and contract manufacturing for specialized, small-volume chemical products.
• Process Chemistry: Integral to scaling up laboratory synthesis routes to commercially viable manufacturing processes under GMP guidelines.

Basic Information

Product Name	Ethyl 3-[4-[2-Hydroxy-3-(Propan-2-Ylamino)Propoxy]Phenyl]Propanoate
CAS No.	81147-95-7
Molecular Formula	C17H27NO4
Molecular Weight	309.40 g/mol
Synonyms	Ethyl 3-(4-{2-Hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl)propanoate; 4-[2-Hydroxy-3-(isopropylamino)propoxy]phenylpropionic Acid Ethyl Ester; Carvedilol Intermediate; BM 14190 Intermediate; (±)-1-(Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol Precursor; Ethyl 4-(2-hydroxy-3-isopropylaminopropoxy)phenylpropionate; (RS)-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol Related Compound A.
EINECS	Contact for details

Quality Control

Our Ethyl 3-[4-[2-Hydroxy-3-(Propan-2-Ylamino)Propoxy]Phenyl]Propanoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We support compliance with ICH Q7 guidelines and can tailor specifications to meet specific customer and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (specify enantiomer)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.