Description

(+/-)-Cgp-12177 Hydrochloride CAS NO 81047-99-6 is a potent and selective β-adrenergic receptor antagonist, widely utilized as a crucial reference standard and research tool in pharmacological studies. Its primary value lies in its high affinity for β1- and β2-adrenoceptors, making it indispensable for investigating receptor binding, signal transduction pathways, and cardiovascular function. This compound is essential for pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuroscience, cardiology, and drug discovery.

Application

• Pharmacological Research: Used as a high-affinity, non-selective β-adrenergic receptor antagonist in receptor binding assays and functional studies.
• Biochemical Tool Compound: Serves as a critical reference standard for characterizing adrenergic receptor subtypes (β1 and β2) in cell-based and tissue-based experiments.
• Drug Discovery & Development: Employed in screening programs and lead optimization for cardiovascular and central nervous system (CNS) therapeutic agents.
• Academic & Clinical Research: Facilitates studies on autonomic nervous system regulation, cardiac function, and metabolic pathways.
• Analytical Standard: Used for method development, validation, and quality control in HPLC, LC-MS, and other analytical techniques within pharmaceutical analysis.

Basic Information

Product Name	(+/-)-Cgp-12177 Hydrochloride
CAS No.	81047-99-6
Molecular Formula	C14H22ClN3O2 • HCl
Molecular Weight	344.26 g/mol (for hydrochloride salt)
Synonyms	CGP 12177 Hydrochloride; CGP-12177 HCl; (±)-CGP-12177 Hydrochloride; 4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-1H-indole-2-carbonitrile Hydrochloride; ICI 12177; CGP12177; CGP 12177A; B-adrenergic antagonist CGP 12177
EINECS	Contact for details

Quality Control

Our (+/-)-Cgp-12177 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccants and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.