Description

(R)-(+)-Metoprolol CAS NO 81024-43-3 is the pharmacologically active enantiomer of the widely used β-1 adrenergic receptor blocker, metoprolol. This high-purity chiral intermediate is critical for the development and manufacturing of enantiomerically pure cardiovascular pharmaceuticals. It is primarily required by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers focused on producing advanced, targeted therapies for hypertension, angina, and heart failure with improved efficacy and reduced side-effect profiles.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiopure (R)-metoprolol and related β-blocker APIs.
• Cardiovascular Drug Research: Used in preclinical and clinical research to study the specific pharmacological effects of the (R)-enantiomer.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for analytical method development and quality control in pharmaceutical labs.
• Asymmetric Synthesis: Valuable starting material or template for chemists developing novel asymmetric synthetic routes to β-adrenergic antagonists.
• Metabolite Studies: Employed in the synthesis and identification of specific drug metabolites for pharmacokinetic and toxicological profiling.

Basic Information

Product Name	(R)-(+)-Metoprolol
CAS No.	81024-43-3
Molecular Formula	C15H25NO3
Molecular Weight	267.36 g/mol
Synonyms	(R)-Metoprolol; (R)-(+)-Metoprolol; (2R)-1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol; (R)-1-Isopropylamino-3-[p-(2-methoxyethyl)phenoxy]-2-propanol; Lopressor (R)-enantiomer; Metoprolol R enantiomer; Dextro-Metoprolol
EINECS	Contact for details

Quality Control

Our (R)-(+)-Metoprolol is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity, suitable for pharmaceutical development. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles. While not necessarily compendial grade, our quality standards align with the rigorous requirements for pharmaceutical intermediates and reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R)-enantiomer
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.