Description

(S)-(-)-Metoprolol CAS NO 81024-42-2 is the single enantiomer form of the widely used β-1 selective adrenergic receptor blocker, metoprolol. This high-purity chiral intermediate is critical for the research and development of enantiomerically pure pharmaceuticals, ensuring targeted therapeutic effects and minimizing side effects. It is an essential building block for advanced pharmaceutical manufacturers, research institutions, and CDMOs focused on cardiovascular drug development, chiral synthesis, and analytical method validation.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Key chiral synthon in the synthesis of enantiopure (S)-metoprolol and its salt forms (e.g., succinate, tartrate).
• Pharmaceutical R&D: Reference standard and starting material for developing novel β-blockers and studying structure-activity relationships (SAR).
• Chiral Resolution Studies: Used as a standard in developing and validating chromatographic methods for enantiomeric separation and purity analysis.
• Process Chemistry: Serves as a critical intermediate in optimizing asymmetric synthesis routes for scale-up and commercial manufacturing.
• Metabolite & Impurity Synthesis: Used to synthesize and identify potential process-related impurities and metabolites for regulatory filings.

Basic Information

Item	Detail
Product Name	(S)-(-)-Metoprolol
CAS No.	81024-42-2
Molecular Formula	C15H25NO3
Molecular Weight	267.36 g/mol
Synonyms	(S)-Metoprolol; (-)-Metoprolol; L-Metoprolol; (S)-1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol; Metoprolol S-(-) isomer; UNII-9V1P7685QH; Metoprolol Impurity C (S-isomer)
EINECS	Contact for details

Quality Control

Our (S)-(-)-Metoprolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity by HPLC, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided and available upon request, supporting regulatory submissions and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.