Description

n-Trifluoroacetyladriamycin-14-o-Hemiadipate is a key synthetic intermediate in the production of advanced pharmaceutical compounds. This specialized chemical is crucial for researchers and manufacturers developing novel anthracycline-based therapeutics, where precise molecular modification is required. It is primarily utilized in pharmaceutical R&D and fine chemical synthesis for creating targeted drug candidates and prodrugs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel anthracycline derivatives and prodrugs for oncology research.
• Anticancer Agent Research: Used in the development and study of new chemotherapeutic agents targeting DNA intercalation and topoisomerase II inhibition.
• Medicinal Chemistry: Serves as a precursor for structure-activity relationship (SAR) studies to optimize drug efficacy and reduce side effects.
• Bioconjugation Studies: Employed in the creation of antibody-drug conjugates (ADCs) and other targeted delivery systems due to its modifiable functional groups.
• Fine Chemical Synthesis: Used in multi-step organic synthesis for producing high-value, complex molecules in controlled environments.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	n-Trifluoroacetyladriamycin-14-o-Hemiadipate
CAS No.	80787-29-7
Molecular Formula	C₃₃H₃₃F₃NO₁₃
Molecular Weight	708.61 g/mol
Synonyms	14-O-[(5-Carboxypentanoyl)]-4'-O-trifluoroacetyladriamycin; 4'-O-Trifluoroacetyl-14-O-(5-carboxypentanoyl)adriamycin; Adriamycin-14-hemiadipate-4'-trifluoroacetate; Doxorubicin-14-O-hemiadipate-4'-O-trifluoroacetate; 7,8,9,10-Tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione 14-O-(5-carboxypentanoate) 4'-O-(2,2,2-trifluoroacetate); Trifluoroacetyl Doxorubicin-14-hemiadipate; AD 143; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our n-Trifluoroacetyladriamycin-14-o-Hemiadipate is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide Certificates of Analysis (COA) with detailed results for all critical parameters, ensuring traceability and compliance with cGMP standards where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.