Description

4-Fluoro-2-Nitrobenzonitrile is a versatile fluorinated aromatic nitrile building block, essential for advanced organic synthesis. Its molecular structure, featuring both a strong electron-withdrawing nitro group and a fluorine atom ortho to the nitrile, makes it a critical intermediate for constructing complex molecules with high precision. This compound is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, dyes, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science: Serves as a building block for advanced polymers, liquid crystals, and organic electronic materials due to its electron-deficient aromatic core.
• Dye and Pigment Manufacturing: Employed in the synthesis of specialized fluorinated dyes and colorants with unique light-fastness properties.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new fluorination reactions and heterocyclic chemistry.
• Ligand and Catalyst Development: Used to create novel ligands for transition metal catalysis, leveraging the nitrile and nitro functional groups for coordination.

Basic Information

Product Name	4-Fluoro-2-Nitrobenzonitrile
CAS No.	80517-21-1
Molecular Formula	C7H3FN2O2
Molecular Weight	166.11 g/mol
Synonyms	2-Nitro-4-fluorobenzonitrile; 4-Fluoro-2-nitrobenzenecarbonitrile; Benzonitrile, 4-fluoro-2-nitro-; 2-Cyano-5-fluoronitrobenzene; 5-Fluoro-2-nitrobenzonitrile; 4-Fluor-2-nitro-benzonitril (German); 4-Fluoro-2-nitrobenzonitril; 80517-21-1 (CAS)
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Nitrobenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Yellow to pale brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	95 - 99 °C
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.